هامارتومای هیپوتالاموس: یک علت نادر بلوغ زودرس مرکزی در کودکان
کد: G-1034
نویسندگان: Homa Ilkhanipoor © ℗
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Precocious puberty is the onset of physical and hormonal features of pubertal development and beginning of secondary sexual characteristics at an earlier age than expected. The onset of puberty before the age of 9 years in males and 8 years in females is considered sexual precocity. The most common cause of precocious puberty in girls is idiopathic. Hypothalamic hamartomas are uncommon congenital malformations that present as precocious puberty, gelastic seizures and/or psychiatric disorders. Treatment may include surgery or gonadotropin-releasing hormone agonists (GnRHa) depending on clinical manifestations. Here, I describe a case of hypothalamic hamartoma diagnosed in a 4‑year 9‑month‑old girl, who presented with early development of secondary sexual characteristics without neurologic manifestations. Physical examination, hormonal study, bone age and pelvic ultrasound findings were consistent with those of precocious puberty. The investigation also included a Hypothalamic hypophysis axis MRI , which revealed a small nodule with regular limits in the left hypothalamic region/ tuber cinereum. GnRHa treatment and neurosurgical follow-ups were initiated promptly. The patient showed a reversal of secondary sexual characteristics and stable hamartoma size.
