بررسی کلینیکی و پاراکلینکی بیماران مبتلا به ب ث ژ طی 32 سال در بیمارستان نمازی
کد: G-1037
نویسندگان: Siavash Soflaei ℗, Anahita Sanaei ©, Seyedeh Sedigheh Hamzavi, Gholamreza Pouladfar, Mohammad Rahim Kadivar, Ali Amanati, Seyede Kowsar Shoja, Maryam Mohammadrezaee, Erfan Taherifard, Sara Heydar
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خلاصه مقاله:
خلاصه مقاله
Abstract Introduction: Bacillus Calmette-Guérin (BCG) vaccine has an acceptable safety record; however, the vaccination can be accompanied by a variety of complications including local and systemic ones. Disseminated BCG infection is one of these complications that is associated with a higher rate of mortality. In the present study, we aimed to identify the demographic and clinical characteristics of these patients. Method: In this retrospective study, patients with a diagnosis of disseminated BCG infection admitted to Namazi Hospital between January 1991 and January 2022 were included. Demographic, clinical, and paraclinical data of these patients were collected. Statistical Package for Social Sciences was used for data management and analysis. Results: 118 patients with a documented diagnosis of disseminated BCG infection were included in the study. The age range was between 1 and 85 months; however, the majority of them were infants. Immunodeficiency was detected in more than half the patients (51.7%) with severe combined immunodeficiency on the top. 43 patients, 36.4%, did not survive the disease. The age of the patients and the status of their immune systems were significantly associated with their outcomes in the hospital course. Conclusions: Disseminated BCG infection could be the first manifestation of a child having an immunodeficiency disease. In this study, it was shown that the common presenting symptoms and signs of these patients could resemble many other pediatric diseases; therefore, as it is associated with a high rate of mortality, a detailed history taking and meticulously performed examination would be crucial not to miss the disease. Keywords: Bacillus Calmette-Guérin vaccine; Disseminated BCG infection; Immune system diseases; Tuberculosi
